Titlebook: Hepatic Stellate Cells; Methods and Protocol Ralf Weiskirchen,Scott L. Friedman Book 2023 The Editor(s) (if applicable) and The Author(s),

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,Generation and Culture of Primary Mouse Hepatocyte–Hepatic Stellate Cell Spheroids,-cultures of primary or stem cell-derived liver cells. Great progress has been made in the development of stem cell-derived liver cultures; however, the liver cells obtained from stem cells do not yet fully recapitulate the phenotype of their in vivo counterparts. Freshly isolated rodent cells remai

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Human Hepatic Stellate Cells: Isolation and Characterization, which produce fibrous scar and make the liver fibrotic. aHSCs are the major source of myofibroblasts and, therefore, the primary targets of anti-fibrotic therapy. Despite extensive studies, targeting of aHSCs in patients provides challenges. The progress in anti-fibrotic drug development relies on

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Single Cell Secretome Analyses of Hepatic Stellate Cells: Aiming for Single Cell Phenomics,key pathogenic cells in liver diseases. Excessive ECM accumulation results in tissue scarring, referred to as liver fibrosis, that progresses to liver cirrhosis (liver dysfunction) and hepatocellular carcinoma. Recent studies using single cell RNA sequencing have discovered various subpopulations of

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Hepatic Stellate Cell Targeting Using Peptide-Modified Biologicals,te cells (HSCs) are recognized as a key therapeutic target in liver diseases as these cells, upon activation during liver damage and ongoing liver inflammation, secrete excessive amounts of extracellular matrix that leads to liver tissue scarring (fibrosis) responsible for liver dysfunction (end-sta

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he Darstellung der Befunde und Diagnosen in Tabellenform mit.Angst vor dem ersten Patientenkontakt? - Das muss nicht sein! ..In diesem praktischen Taschenbuch finden sich die g?ngigen Anamnese- und Untersuchungstechniken für die orientierende klinische Untersuchung und im zweiten Teil auch die jewei

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