Titlebook: Helicobacter pylori Infection; Pathophysiology, Epi T.C. Northfield (Professor of Gastroenterology),M. Book 1993 Springer Science+Business

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Pathogenesis of infections due to persistent bacteria at mucosal surfacesssues. Since the discovery of . in 1983 there has been intense interest in this organism because of its relationship to ulcer disease, among other maladies. However, the pathophysiology of . infection is largely unknown. In this chapter I review the major points that have been learned about . pathog

誹謗

Host responses model studies all implicate this organism as the aetiological agent inducing gastric inflammation. Many infected subjects remain asymptomatic. However, the increasing importance of . in peptic ulcer disease., gastric adenocarcinoma (Chapter 2 of this volume) and gastric MALT lymphoma.,. stresses th

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Mucosal defence than 70 years. In 1910 Schwarz hypothesized that peptic ulcer is a product of self digestion, which results from a ‘disproportion in the normal balance between the autopeptic power of gastric juice and the protective forces of the gastric mucous membrane’. Since this time various abnormalities of m

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The precancer-cancer sequence. There is growing evidence from the fields of epidemiology and pathology that the two events may be linked. In this chapter the morphological steps in the progression across this spectrum are examined whilst the epidemiological and pathophysiological data are to be found in Chapters 2 and 10. The t

LANCE

Microbiological tests in common use, whereas the newer, molecular methods are research tools that may be widely adopted in the near future to aid diagnosis. The culture of . is often referred to as the ‘gold standard’ of methods for the detection of this microorganism because it is specific. However, the sensitivities o

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Serologymportant that clinicians have rapid access to accurate information about the . status of dyspeptic patients. Frequently this information will be needed prior to endoscopy, and therefore requires non-invasive diagnostic test systems. To date, two such non-invasive systems have been developed; serolog

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Vaccination possibilities and probabilitiesected with this organism, most are asymptomatic. In those in whom ulceration does occur, successful treatments are available, after which reinfection is unlikely. This situation has changed dramatically, however, with the growing realization that long-term infection with . is not without risk, i.e.