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Titlebook: Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection; Alexzander A.A. Asea,Ian R. Brown Book

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發(fā)表于 2025-3-21 19:05:26 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection
編輯Alexzander A.A. Asea,Ian R. Brown
視頻videohttp://file.papertrans.cn/426/425010/425010.mp4
概述Written by leaders in the field of neurodegenerative diseases and neuroprotection.Provides up-to-date reviews on the most recent concepts of the role of heat shock proteins in repair and protective me
叢書名稱Heat Shock Proteins
圖書封面Titlebook: Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection;  Alexzander A.A. Asea,Ian R. Brown Book
描述With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have been termed ‘protein misfolding disorders’ that are char- terized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a the- peutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Heat shock proteins are protein repair agents that provide a line of defense against misfolded, aggregati- prone proteins. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV). Key basic and clinical research laboratories from major u
出版日期Book 2008
關鍵詞Chaperones; HSP; Nervous System; Parkinson; Protein folding; Stress proteins; neurons
版次1
doihttps://doi.org/10.1007/978-1-4020-8231-3
isbn_softcover978-90-481-7813-1
isbn_ebook978-1-4020-8231-3Series ISSN 1877-1246 Series E-ISSN 1877-1254
issn_series 1877-1246
copyrightSpringer Science+Business Media B.V. 2008
The information of publication is updating

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沙發(fā)
發(fā)表于 2025-3-21 20:37:54 | 只看該作者
Chaperones and Polyglutamine Expansion Disordersquality control. Hence, dysfunctional cellular protein quality control presents a very basic and fundamental problem of protein misfolding and therefore of polyglutamine toxicity. Thus, the elucidation of the interplay between polyglutamine expansion proteins and molecular chaperones contributes pro
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地板
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Heat Shock Proteins Hsp70 and Hsp27 and Neural Cellular Protectionntaining cell homeostasis..Experimentally, the induction of Hsp27 and Hsp70 in neurons and glia is usually through stress, or altered gene expression. If levels of Hsp27 or Hsp70 can be increased to higher levels by drug or supplement administration, increased levels of Hsps may be a therapy for neu
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發(fā)表于 2025-3-22 19:48:58 | 只看該作者
Molecular Chaperones and Protection in Animal and Cellular Models of Ischemic Strokeolved. Despite a great deal of study, much remains to be learned about the multifaceted effects of Hsps in cerebral ischemia. The endogenous stress response remains a model of cell protection with promise for the development of novel therapies for ischemic brain injury
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發(fā)表于 2025-3-23 01:01:59 | 只看該作者
Strategies for Conferring Neuroprotection and Countering the High Threshold for Induction of the Stralso contribute to constitutive and stress-induced regulation of heat shock genes and are potential therapeutic targets. Another approach is to screen chemical libraries using a test system that expresses motor neuronal properties, with positive hits being validated .. The most effective therapies w
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