Titlebook: Heart Failure; Johann Bauersachs,Javed Butler,Peter Sandner Book 2017 Springer International Publishing AG 2017 Heart failure.Reduced ejec

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Vasopressin and Vasopressin Antagonists in Heart Failure,ins poor. Hyponatremia is prevalent in HF patients and has been suggested as a contributor to poor response to standard therapy. Elevated levels of arginine vasopressin (AVP), a peptide hormone produced in the hypothalamus, play a role in development of hyponatremia, and AVP and its surrogate, copep

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Platelet-Derived Growth Factor in Heart Failure,ion fraction. Any treatment option that augments these myocardial processes may therefore be of significant value. The platelet-derived growth factor (PDGF) family is involved in a wide range of growth processes and plays a key role in both regulating angiogenesis and mesenchymal cell development. T

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Wnt Signaling in Cardiac Remodeling and Heart Failure, Accumulating evidence demonstrates that Wnt signaling is also activated during cardiac remodeling and heart failure. In this chapter, we will provide a brief overview of Wnt signaling in all its complexity. Then we will discuss the evidence for its involvement in the development of cardiac hypertro

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Gene Therapy in Heart Failure,y therapies which can address root cause myocyte dysfunction. Modern drugs, surgeries, and state-of-the-art interventions are costly and do not improve survival outcome measures. Gene therapy is an attractive strategy, whereby selected gene targets and their associated regulatory mechanisms can be p

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Noncoding RNAs in Heart Failure,on of healthy heart into the failing one; nevertheless better understanding of the complex genetic regulation of maladaptive remodeling in the failing heart is essential for new drug discovery. Noncoding RNAs are key epigenetic regulators of cardiac gene expression and thus significantly influence c

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Lauriane Y. M. Michel,Jean-Luc Balligandn Betrachtung allerdings scheinen in den Texten und Kunstwerken vor allem die bekannten Topoi des Exotismus und der Utopien neu aufzuleben: Insbesondere die nicht-okzidentale "Neue Welt" stellt eine offenbar bessere, ursprünglichere Welt voller Mythen und sch?pferischer Energie dar.