Titlebook: Handbook on Immunosenescence; basic understanding Tamas Fulop,Claudio Franceschi,Graham Pawelec Book 2009 Springer Science+Business Media

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Lymphocytes Sub-Types and Functions in Centenarians as Models for Successful Ageing In addition, a tight regulation of the immune response has to occur in order to avoid excessive inflammation and potential autoreactivity towards self components. In the last years, the discovery and the characterization of new lymphocytes subsets, including regulatory T (Treg)-cells and Natural Ki

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Mouse Models and Genetics of Immunosenescenceespond to infections. Thereby the quality of longer lifespan enjoyed by modern man is significantly compromised. Furthermore, higher mortality in the elderly from infections, autoimmune disease and cancer is associated with decline in the immune function. The use of rodent models has yielded critica

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Clonal Culture Models of T-cell Senescencecell analysis is challenging and many age-associated alterations described are the result of changes in the proportions of the ever-increasing numbers of different T-cell subsets rather than changes to the cells per se. One model avoiding this problem utilises monoclonal populations cultured long-te

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Mouse Models of Influenzad B are important causes of disease in humans. Transmitted via aerosol, the virus possesses two major surface, hemagglutinin (HA) and neuraminidase (NA). HA has binding specificity for sialic acid, and allows viral attachment and entry into the cell. NA cleaves sialic acid residues off glycoproteins

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A Transgenic Dwarf Rat Strain as a Tool for the Study of Immunosenescence in Aging Rats and the Effell-known nutritional intervention for longevity in laboratory animals, retards immunosenescence and modulates the immunosystem. These effects of CR could contribute partly to extending the lifespan. A transgenic (Tg) dwarf rat strain, in which the growth hormone (GH) axis is selectively suppressed,

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Mathematical Modeling of Immunosenescence: Scenarios, Processes and Limitationsis paper we outline basic variables important for modeling aging immunity. We discuss the role of evolution in shaping pattern of aging in the immune system of modern humans. We investigate mathematical models of postnatal changes in the population of peripheral T-cells, effects of the antigenic loa

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Age, T-cell Homeostasis, and T-cell Diversity in Humans surface immunoglobulin on B cells facilitate the recognition of foreign structures found on tumors and pathogens that have overwhelmed the defenses of the innate immune system. Because pathogen encounters and neoplasic transformations are inherently unpredictable, an immense lymphocyte receptor rep

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The Role of T-regulatory Cells in Immune Senescencene function was noticed more than 20 years ago and was recognized by a number of highly cited publications [2]. However, the lack of a specific phenotype for these cells, and an inability to document precise physiological mechanisms for their action, limited their investigation by detailed experimen

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