Titlebook: Handbook of the Extracellular Matrix; Biologically-Derived F. Raquel Maia,J. Miguel Oliveira,Rui L. Reis Reference work 2024 Springer Natur

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Extracellular Matrix Bioscaffolds: Structure-Functiont differ between tissue types. The ECM supports the healthy, functional homeostatic state of tissues and provides signals that support reparative mechanisms following injury. The natural regenerative properties of the ECM make it an ideal material for bioscaffold formulations and applications in reg

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Extracellular Matrix Bioactive Molecules and Cell Behavior Modelingelopment and homeostasis. ECM components form a structurally stable tissue composite that renders it mechanical strength. The ECM is also a reservoir of growth factors and biomolecules that control fundamental cellular and biological processes such as proliferation, differentiation, apoptosis, and a

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Extracellular Matrix Isolation: Sources and Methodsbe obtained by using chemical, physical, and enzymatic methods. The isolation of specific ECM components is feasible, while the achievement of fully preserved ECM complexity, including the preservation of the interactions between the different matrix components, is the main goal of the most recent E

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Strategies for Mimicking Extracellular Matrixssues and direct cells toward regeneration. Therefore, mimicking the structural, mechanical, and physical properties of ECM is of interest to produce the ideal tissue-engineered device. However, producing such biomaterials is not an easy task because of the complexity of tissues. In this chapter, th

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Extracellular Matrix Remodeling on Cancer Progressionrous proteins, which give the ECM its dynamic shape. In terms of tissue development and homeostasis, the ECM plays a major role. In addition, it serves as one of the major structural components of the tumor microenvironment. The ECM undergoes continuous remodeling processes due to the progression of

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