Titlebook: Handbook of the Cerebellum and Cerebellar Disorders; Mario U. Manto,Donna L. Gruol,Roy V. Sillitoe Reference work 2022Latest edition Sprin

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Development of Cerebellar Nucleihe deep white matter adjacent to the roof of the fourth ventricle. The CN are comprised of multiple neuron types including large glutamatergic projection neurons, GABAergic projection neurons, and small GABAergic interneurons. Hodologically, CN receive afferent projections from Purkinje cells and gi

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Synaptic Remodeling and Neosynaptogenesisns in the rodent olivocerebellar path, looking at the changes in synaptic contacts between climbing fibers and Purkinje cells, during developmental synapse formation, selective synapse stabilization, and synaptic reformation. Examining the interactions between climbing fibers and Purkinje cells duri

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Synaptogenesis and Synapse Eliminationre crucial steps for functional neural circuit formation in the developing nervous system. Shortly after birth in murine life, excitatory synapses are present on the somata of Purkinje cells (PCs) from climbing fibers (CFs) that originate from neurons in the inferior olive of the contralateral medul

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Genes and Cell Type Specification in Cerebellar Developmentnning to understand this process of cell specification; however, evidence suggests that it occurs in a stepwise fashion and it is likely that each step requires the coordinated expression of a unique set of genes working in concert with environmental signals. The cerebellum is an excellent model sys

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Hormones and Cerebellar Developmentfluences from endocrine cells. Of the circulating hormones, a group of small lipophilic hormones including steroids (corticosteroids, progesterone, androgens, and estrogens) and thyroid hormones help mediate environmental influences on the cerebellum. Receptors for such lipophilic hormones are mainl