Titlebook: Handbook of Neurotoxicity; Richard M. Kostrzewa Reference work 20141st edition Springer Science+Business Media New York 2014

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Dopamine and L-dopa as Selective Endogenous Neurotoxinsf exogenous neurotoxins depends on their affinity to the dopamine transporter. However, dopamine and 3,4-L-dihydroxyphenylalanine (L-dopa) are synthesized in dopaminergic neurons and are likewise able to induce neurotoxicity. The possible molecular mechanisms involved in dopamine and L-dopa neurotox

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MPTP Neurotoxicity: Actions, Mechanisms, and Animal Modeling of Parkinson’s Diseaseed by MPTP rejuvenated PD research and generated a number of studies aimed at elucidating the mechanisms of action of MPTP. Remarkably, these molecular mechanisms turned out to be critical also for the survival of DA neurons in idiopathic PD. In this chapter we report the main concepts developed ove

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Glutamate as a Neurotoxin can trigger passive and active forms of neuronal death in the CNS via excessive activation of glutamate receptors. This phenomenon has been named excitotoxicity. Excitotoxicity has been implicated in the pathogenesis of acute and chronic neurodegenerative disorders. However, despite overwhelming pr

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