Titlebook: Handbook of Neurochemistry and Molecular Neurobiology; Practical Neurochemi Abel Lajtha (Director),Glenn Baker,Andrew Holt Reference work 2

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Cytochrome P450 Reactions in the Human Brain,ften carried out by the enzyme cytochrome P450. First noted as a hepatic heme‐containing enzyme, we now know that ‘cytochrome P450’ constitutes a superfamily in humans, containing dozens of individual but related enzymes. Because of its heavy presence in liver, cytochrome P450 is often thought of as

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Practical Enzymology,ropriately, and this requires some understanding of the kinetic behavior of the enzyme toward the substrate used. Furthermore, such an understanding is vital if the inhibitory effects of a drug are to be assessed appropriately. This chapter outlines key principles that must be adhered to, and descri