Titlebook: Handbook of Chronic Myeloid Leukemia; Timothy P Hughes,David M Ross,Junia V Melo Book 2014 Springer International Publishing Switzerland 2

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Introduction,Chronic myeloid leukemia (CML) is a myeloproliferative disease of the hematopoietic stem cell (HSC). In its natural history, CML is a tri-phasic disease, presenting predominantly in a chronic phase averaging around 5–7?years, but spanning from between a few months to over 20?years.

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Diagnosis,When a patient presents with suspected chronic myeloid leukemia (CML) appropriate assessments are needed to confirm the diagnosis and stage of disease, and to assign a risk score to that patient.

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https://doi.org/10.1007/978-3-319-08350-6BCR-ABL signaling; Hematology; Leukemia; Tyrosine kinase inhibitors; pharmacotherapy

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https://doi.org/10.1007/978-3-030-01294-6 not. Palliation with alpha interferon (IFNα) could prolong survival substantially for the 15–30?% of patients who had IFNα-responsive disease but quality of life for these patients was often markedly impaired.