Titlebook: Handbook of Chemical Biology of Nucleic Acids; Naoki Sugimoto Living reference work 20220th edition DNA.RNA.Riboswitch.Ribozyme.Quadruple

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Studying Nucleic Acid-Ligand Binding by X-Ray Crystallography,, this method has provided the fundamental details of nucleic acid structure, starting with the DNA double helix, and now extending to encompass the diversity of both DNA and RNA and their interactions with both small molecules (ligands) and proteins. The technique generates primary structural data

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Chemistry of Cyclic Dinucleotides and Analogs,le, a CDN composed of two guanine bases is called cyclic-di-GMP (c-di-GMP). CDNs are biosynthesized from two nucleoside 5′-triphosphates by cyclase enzymes, such as guanylate cyclase which synthesizes c-di-GMP. Since the 1980s, as the biological significance of CDNs has become clear, chemists have f

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Labeling and Detection of Modified Nucleic Acids,re than 17 and 160 different types of modified bases that have been discovered in DNA and RNA. The nucleic acid epigenetics were emerged to understand the specific biological functions of these DNA and RNA modifications. For this purpose, the development of detection methods of nucleic acid modifica