Titlebook: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics; William D. Figg,Howard L. McLeod Book 20041st edition Humana Press 2004 DNA.

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https://doi.org/10.1007/978-1-349-17060-9lop new treatment strategies that address those factors. The development of effective chemotherapeutic agents for the treatment of solid tumors depends, in part, on the ability of those agents to achieve cytotoxic drug concentrations or exposure within the tumor ..

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Design Guidelines and Scenarios—A Summaryhe process of knowledge discovery when applied to PM model development ensures that information embedded in the data is thoroughly understood and apporopriately applied .. Modern data analysis methods and modern statistical software such as S-Plus. have revolutionized the manner in which PM analyses can be performed.

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Preclinical Screening for New Anticancer Agents,r activity. Only a certain number of drugs and concepts, however, can be evaluated clinically because of cost and ethical considerations. A preselection, called the screening process, is therefore required. The aim of screening efforts is to identify products that will produce antitumor effects matc

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