Titlebook: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics; Michelle A. Rudek,Cindy H. Chau,Howard L. McLeod Book 2014Latest edition Spr

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Donald E. Thomas,Philip R. Moorbys chapter focuses on the most up-to-date clinical trials involving pharmacogenomics and anticancer therapy. A brief introduction of drug development and the difference between somatic and germline DNA mutations sets up the chapter for understanding the progress which has been made in regard to indiv

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,Verilog – A Tutorial Introduction,e excision repair (NER) pathway is the mammalian DNA repair mechanism that removes bulky DNA adducts induced by DNA damaging chemotherapeutic agents. Platinum compounds induce their cytotoxic effect by binding to a DNA molecule in the form of a platinum-DNA-adduct. The NER pathway is the main mechan