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Titlebook: HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design; A Review of 20 Years Marc H V Van Regenmortel Book 2019 Springer Nature Switzer

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What Is a B Cell Epitope or ability to induce antibodies in a competent vertebrate host. Failure to make this distinction partly explains why no successful peptide-based vaccines have yet been developed. Methods for predicting the epitopes of proteins are discussed and the reasons for the low success rate of epitope prediction are analyzed.
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發(fā)表于 2025-3-28 00:38:45 | 只看該作者
Commentary: Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking tried, without success, to transform Env epitopes of known structure into effective vaccine immunogens, because they thought that epitopes that bind to affinity-matured bnMabs would also be able to induce similar antibodies when used as immunogens (Van Regenmortel 2012a).
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Book 2019in recent years to develop a preventive HIV vaccine. Providing a detailed review and analysis of studies published from 1998 to the present day, it examines the likely reasons for the failure to develop an HIV vaccine despite multi-million dollar investments..
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