Titlebook: HCV/Oxidative Stress and Liver Disease; Kiwamu Okita (Professor and Chairman) Conference proceedings 2003 Springer Japan 2003 DNA.RNA.canc

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Role of Hepatitis C Virus in Hepatocarcinogenesis: Oxidative Stress in the Absence of Inflammation,t of hepatocellular carcinoma (HCC). In the pathogenesis of HCC associated with HCV, it remains controversial whether the virus plays a direct role or merely an indirect role. Through the use of a transgenic mouse model established by us, it has become evident that the core protein of HCV has an onc

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,Reduced Chemical Hepatocarcinogenesis in Interferon-γ Receptor Knockout Mice,infiltration was observed in the livers of mice treated with chemical hepatocarcinogens, the pathophysiological role of the inflammatory response is not well defined in the process of carcinogenesis. To approach this question, mice were exposed to a chemical hepatocarcinogen, diethylnitrosamine (DEN

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Fewer Somatic Mutations of Mitochondrial DNA in Noncancerous Liver Tissue of Patients with Hepatocetochondrial DNA (mtDNA) than in nuclear DNA. In this study, we examined the number of mtDNA mutations in paired cancerous and noncancerous tissue from the same resected specimen from 59 patients with Hepatitis C virus-related HCC. Some patients had undergone interferon (IFN) therapy. Residues of the