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Gut-Microbiota as a Therapeutic Intervention for Cognitive Damage, in the pathogenesis of several gastrointestinal and extraintestinal disorders, and it is showing signs of evolving into a significant disease-controlling factor. Through the increasingly well-defined gut microbiota–brain axis (GMBA), an altered gut microbiome (GM) has more recently been linked to m

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Pharmacological and Nutritional Approaches to Modulate Microglial Polarization in Cognitive Senesceare responsible for maintaining brain homeostasis. Normally older people exhibit a high inflammatory condition in brain. Thus any small insult will trigger the microglia activation and polarize into pro-inflammatory (M1) and anti-inflammatory (M2) states. Microglia acts as a double-end sword by both

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,Role of Gut Brain and Gut Oral Axis in Progression of Parkinson’s Disease with Special Focus on Gut of studies are being done to explain the connection between the prevalence of Parkinson’s disease and gut microbial dysbiosis. Both the central nervous system (CNS) and the enteric nervous system (ENS) are affected in a specific way by gut microbial dysbiosis, suggesting that there is a gut-microbi

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The Gut Microbiome-Induced Changes in Brain Immune System and Their Role in Epilepsy,ilepsy. Epilepsy, a chronic neurological disorder characterized by unpredictable seizures, affects millions globally. While traditionally the brain is the focus of treatment, emerging research suggests a potential link between the gut microbiome and epilepsy. When left untreated, these seizures have

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Gut Microbiome: A Key Factor in Ageing and an Aim for Anti-senescence Intervention,e immune system deterioration in the ageing intestinal epithelium. There is evidence that the microbiome structure may have an impact on how quickly people age. These changes take place over time gradually. The age-related changes, including nutrition, frailty, and inflammation have a major impact o

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https://doi.org/10.1007/978-3-319-54133-4ecognized as tremendous regulators of overall host pathophysiology. Interestingly, the central nervous system (CNS) features as a key target of the gut microflora. Recent studies indicate that the bidirectional interactions of the microbiota-gut-brain axis play critical roles in influencing a pletho

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System Dynamics: Main Concepts,s been found to be a critical regulator of many disease conditions. This correlation between the gut microbiota-brain axis and neurodegeneration has been established by recent research, which suggests that changes in the gut microbiome may be a contributing factor. This has made it possible to inves