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,Stabilità e controllo neuroumorale,ming of HSCs and progenitor cells during hematopoiesis, in order to produce in response to the respective immunological challenge the appropriate amounts of innate and adaptive immune cells. Furthermore, in the context of the process of inflammation epigenetic programming of innate immune cells lead

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ANNUL

The Basal Transcriptional Machinery,tional machinery interacts via another multiprotein complex of coactivators, termed the MED complex, with a large variation of transcription factors. In parallel, the MED complex coordinates the action of cofactors of transcription factors, some of which are chromatin modifying enzymes.

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Chromatin Remodeling and Organization,ies, that contain high concentrations of Pol II. Transcription factories function as an attractor for commonly regulated genes with shared nuclear positions. This suggests that the transcriptional status of a gene is based on the position in the sphere of the nucleus.