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Inhibition of arginine synthesis by urea: A mechanism for arginine deficiency in renal failure whic20 min . experiments, 4 m1/100 g body weight of 1.7 M urea or 1.7 M NaCI were injected intra-peritoneally into 5 male Wistar rats. Two hours after the intra-peritoneal injection of urea or 1.7 M NaC1, blood, liver and kidney were obtained by the freeze cramp method and amino acids were determined by

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Smooth muscle and NMR review: An overview of smooth muscle metabolism,ortant contributions with regard to the intracellular pH and ionic status. For example, the intracellular free Mg. ([Mg.],) can be measured with NMR simultaneously with ATP concentrations and NMR has shown us that the [Mg.], is highly protected in the muscle (within confined range), but also respond

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Methyl group deficiency and guanidino production in Uremia,stance known to produce vascular damage. Even in healthy subjects intake of choline together with methionine is insufficient to satisfy total metabolic requirements for methyl groups. In end-stage renal disease, therefore, protein restriction contributes to the build-up of toxins in uremia. Replacem

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L-Canavanine as a radiosensitization agent for human pancreatic cancer cells,ith radiation when either PANC-1 or MIA PaCa-2 cells were exposed to L-canavanine for 72 h prior to irradiation. These results suggest that L-canavanine in combination with radiation may have clinical potential in the treatment of pancreatic cancer. (Mol Cell Biochem . 37-43, 2003)

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The clinical syndrome of creatine transporter deficiency,ever, the skeletal muscle demonstrates the presence of creatine and phosphocreatine which correlates clinically with normal structure and function. Female carriers demonstrated impairments in confrontational naming and verbal memory assessments..This new neurological syndrome is associated with deve

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A role for guanidino compounds in the brain,ns and accumulated free radicals..Arginine is a substrate of nitric oxide production by nitric oxide synthase. a-Guanidinoglutaric acid is a generator of superoxide, hydroxyl radicals and nitric oxide, and induced C6 glial cell death. On the other hand, aminoguanidine is a free radical scavenger. En