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Growth Hormone Secretion In Congestive Heart Failure,timulates GH release and somatostatin, which exists both as 14 and 28 amino acid peptides, which inhibits GH secretion. GH secretion is regulated by negative feed-back and neural control mechanisms. Both GH and IGF-1 inhibit GH secretion after intraventricular injection by promoting hypothalamic som

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The growth hormone axis in cachectic patients with chronic heart failure: evidence for acquired grot ventricular impairment which leads to secondary changes in other organs with consequent symptoms like dyspnoea, muscular fatigue and exercise intolerance. It has long been recognised that significant body wasting (i.e. weight loss) is also an important feature of severe CHF. This dates back to the

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Growth Hormone Treatment in Experimental Heart Failure,ssues are thought to be either direct or mediated by IGF-I. IGF-I is synthesized in multiple tissues including the heart and some of the effects have been suggested to be paracrine or autocrine (1-4). Both GH and IGF-I receptors are expressed in the heart and provide possibilities for GH and IGF-I s

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Effect of Chronic Growth Hormone Treatment in Heart Failure, is aimed at alleviating the symptoms of heart failure. Growth hormone (GH) and insulin like growth factor (IGF-1) are involved in several physiological processes such as the control of muscle mass and function, body composition and regulation of nutrient metabolism (1,2). The roles of GH and IGF-1

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Does the Growth Factor Approach Have a Future in the Treatment of Human Heart failure?, of linear growth and energetic metabolism, and to the maintenance of skeletal muscle growth and performance (1). Over the past few years, a wealth of data from both animal and human studies have enlarged the spectrum of GH’s action even further. GH is now well recognized to be essential for cardiac

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