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Physiological Effects of Growth Hormone on the Heart, idiopathic dilated cardiomyopathy and in congestive heart failure has also been recently investigated with controversial results (3-5). The influence of the GH/IGF-I axis on the heart is displayed at different levels (Fig.1). In this chapter recent knowledge on GH/IGF-I effect on the heart are revi

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Growth Hormone Secretion In Congestive Heart Failure,erized by obtaining blood samples every 20 or 30 minutes throughout a 24-hour period under non stressful conditions. During most of the day, plasma GH levels of normal adults are less than 5 ng/mL, with one or two sharp spikes three to four hours after meals. The most consistent period of GH secreti

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Growth Hormone and Skeletal Muscle Function,uscle performance did not change (4). In hypophysectomized animals GH administration has induced an increase in muscle mass and activity of polyribosomes, indicative of enhanced muscle protein synthesis (5). The strong link between GH and skeletal muscle growth has been convincingly demonstrated by

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Igf-1 And The Heart,other factors, like insulin or nutrition, also influence IGF I production. Both endogenous and administered IGF I mimic trophic effects of pituitary GH. In contrast, some effects of administered IGF I on intermediary metabolism are opposite to those of GH (6, 7). Moreover, the two hormones act by di

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