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書目名稱Group Sequential and Confirmatory Adaptive Designs in Clinical Trials影響因子(影響力)




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Group Sequential and Confirmatory Adaptive Designs in Clinical Trials

Habituate

Adaptive Group Sequential Teststhis chapter on two-stage adaptive designs with an adaptation of the sample size, although the method allows for other types of adaptations such as changing test statistics or changing hypotheses, as well as for the multi-stage generalization.

損壞

Repeated Significance Testst with a brief historical survey of group sequential tests. The notation and the construction of statistical tests that are based on the repeated significance testing approach are described in the following section. We then address the basic issues—power and average sample size—for the assessment of

Pedagogy

召集

Procedures with Unequally Sized Stagesf using the decision boundaries designed for equally sized stages to the more general case of unequally sized stages. We also briefly describe a worst case scenario adjustment procedure. We then sketch the use of designs with prefixed sample sizes that need not to be equal to each other. A more gene

召集

中古

Applicationsclinical trials. These are one- and two-sample tests for normally distributed observations where the variance .. is unknown, one- and two-sample tests for binary data, and statistical inference on time-to-event (survival) data. For survival data analysis, we will slightly modify the notation in orde

傷心

鞭打

Decision Tools for Adaptive Designsal is continued, how to design the remainder of the trial. This raises the important question of how to make the decisions on potential design modifications. On the one hand, such decisions require suitable methods and statistics to summarize the relevant information from the interim data, and there