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Titlebook: Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins; Raphael Enoque Ferraz de Paiva Book 2018 Sp

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發(fā)表于 2025-3-21 18:02:07 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
編輯Raphael Enoque Ferraz de Paiva
視頻videohttp://file.papertrans.cn/388/387310/387310.mp4
概述Nominated as an outstanding Ph.D. thesis by the University of Campinas, Brazil.Presents an innovative approach, using gold chemistry to target zinc finger proteins.Explores the use of Travelling-Wave
叢書名稱Springer Theses
圖書封面Titlebook: Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins;  Raphael Enoque Ferraz de Paiva Book 2018 Sp
描述.This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling..
出版日期Book 2018
關(guān)鍵詞Gold Complexes; Nucleocapsid Protein NCp7; Human Trabscription Factor Protein 1 Sp1; Zinc Finger Protei
版次1
doihttps://doi.org/10.1007/978-3-030-00853-6
isbn_softcover978-3-030-13150-0
isbn_ebook978-3-030-00853-6Series ISSN 2190-5053 Series E-ISSN 2190-5061
issn_series 2190-5053
copyrightSpringer Nature Switzerland AG 2018
The information of publication is updating

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發(fā)表于 2025-3-21 21:20:29 | 只看該作者
Probing Gold: X-Ray Absorption Spectroscopyra. The viral NCp7 ZnF2 was compared to the human transcription factor Sp1 ZnF3.?We examine the effects of the zinc coordination sphere in dictating reactivity and delineating the intimate mechanisms of metal ions substitution in a ZnF template. In the case of Au(I) compounds, we confirm the Lewis a
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發(fā)表于 2025-3-22 04:12:22 | 只看該作者
Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
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發(fā)表于 2025-3-22 07:35:18 | 只看該作者
https://doi.org/10.1007/978-1-4419-6481-6ra. The viral NCp7 ZnF2 was compared to the human transcription factor Sp1 ZnF3.?We examine the effects of the zinc coordination sphere in dictating reactivity and delineating the intimate mechanisms of metal ions substitution in a ZnF template. In the case of Au(I) compounds, we confirm the Lewis a
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發(fā)表于 2025-3-22 10:28:59 | 只看該作者
https://doi.org/10.1007/978-3-030-00853-6Gold Complexes; Nucleocapsid Protein NCp7; Human Trabscription Factor Protein 1 Sp1; Zinc Finger Protei
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Au(III) Series with ,C,N and ,N,N′ Ligandscesses. On the other hand, stabilizing Au(III) represents an interesting synthetic challenge, given the wide variety of possible strategies available.?For that reason, we decided to explore the stabilization of Au(III) using the N^C donor 2-benzylpyridine (bnpy) ligand and compare it to the classic bipy-like N^N coordination motif.
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins978-3-030-00853-6Series ISSN 2190-5053 Series E-ISSN 2190-5061
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