Titlebook: GnRH: The Master Molecule of Reproduction; Andrea C. Gore Book 2002 Springer-Verlag US 2002 Gonadotropin.Mamma.anatomy.behavior.evolution.

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Neuroanatomy of the GnRH-1 System,H-1 neurons have their perikarya in the preoptic area (POA) and anterior hypothalamic regions, and these cells project a neuronal process to the median eminence. There, GnRH is released from the neuroterminals into portal capillary vessels leading to the anterior pituitary gland. In fish, GnRH-1 neu

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GnRH Pulsatility, et al., 1998; Stojilkovic et al., 1994; Terasawa, 1998 for reviews). GnRH pulsatility occurs in all vertebrate species studied to date. Each pulse of GnRH that is released into the portal circulation stimulates the release of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating horm

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GnRH Neurons: Changes Across the Life Cycle, in hypophysiotropic GnRH neurons are intrinsic to these cells, and others are due to alterations in inputs that affect their function. The following discussion of changes in GnRH neurons across the life cycle of the organism will be broken down into four developmental phases. First, the embryonic o

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Factors Regulating GnRH Neurons,e this apparent multiplicity of inputs may seem redundant, in fact it is crucial for the organism to be able to integrate information about the internal homeostatic milieu, as well as external stimuli, in order to ensure that reproduction and behavior are coordinated. Moreover, while inputs to GnRH

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The GnRH Gene,d hypothalamus, and responsible for hypophysiotropic function, is the focus of the current chapter. The proGnRH-1 gene has been cloned in a number of species including rats, mice, humans, teleost fish, amphibians, and birds (Adelman et al., 1986; Hayflick et al., 1989; Mason et al., 1986; Seeburg an

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Multiple GnRH Molecules, Phylogeny and Evolution,ls to have access to the portal capillary system leading to the anterior pituitary, or directly to the pituitary gland itself in fish. While it was thought for many years that this was the only location of GnRH cells in the brain, at least two other populations of GnRH neurons have been discovered i

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