Titlebook: Glycoprotein Hormones; Structure, Function, Joyce W. Lustbader,David Puett,Raymond W. Ruddon Conference proceedings 1994 Springer-Verlag Ne

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Regulationszentren visceraler FunktionenIn humans, maintenance of pregnancy requires extending the lifetime of the corpus luteum, which produces essential steroids. The signal for this maintenance is provided by . (hCG), a dimeric glycoprotein hormone produced by the trophoblast cells of the early embryo. The absence of hCG would result in rapid termination of early pregnancy.

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Die Kristalle und ihr Stoff bestandThere appears to be only a single gene for the gonadotropin α-subunit in humans (1, 2), but the α polypeptide may combine noncovalently with any of several β-subunits to form one of the heterodimeric hormones, LH, FSH, TSH or hCG. Less commonly appreciated is the notion that substantial quantities of α are secreted in uncombined or “free α” forms.

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Human Chorionic Gonadotropin: Progress in Determining Its Tertiary StructureIn humans, maintenance of pregnancy requires extending the lifetime of the corpus luteum, which produces essential steroids. The signal for this maintenance is provided by . (hCG), a dimeric glycoprotein hormone produced by the trophoblast cells of the early embryo. The absence of hCG would result in rapid termination of early pregnancy.

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978-1-4613-8388-8Springer-Verlag New York, Inc. 1994

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Coordinate Regulation of the Gonadotropin Subunit Genes in Pituitary and Placenta and nuclear protein purification in cell culture model systems, several of the transcriptional regulatory proteins involved in controlling expression of the CG genes in placental trophoblast cells (JEG-3 cell line) and the LH genes in pituitary gonadotrope cells (αT3-1 cell line) have been identifi