Titlebook: Glutamate and Neuropsychiatric Disorders; Current and Emerging Zoran M. Pavlovic Book 2022 Springer Nature Switzerland AG 2022 Aggression.A

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Glutamate-Based Treatment for Amyotrophic Lateral Sclerosis/Motor Neuron Disease,n, synaptic plasticity, learning and memory consolidation, arousal, and behavior. Upon certain circumstances, the glutamate homeostasis can be severely affected by the overproduction of this excitatory neurotransmitter, ultimately leading to neurodegenerative events via excitotoxic mechanisms. There

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Pharmacological Role of Glutamate Transporters in Substance Use Disorders,diction requires the identification of targetable neurobiological mechanisms. As the primary excitatory neurotransmitter in the brain glutamate possesses a significant role in plasticity, learning, and memory, and represents a promising neurotransmitter of focus for intervention in the etiology of S

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The Role of Glutamate Dysregulation in the Etiology of ADHD,s are briefly discussed. The glutamate system in general and its potential role in ADHD are thoroughly reviewed evaluating both preclinical and clinical data. The current ADHD treatments that act on the glutamate system, memantine and atomoxetine, are discussed. The chapter concludes with a discussi

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Glutamate, Glutamatergic Drugs and Schizophrenia,logy of schizophrenia. Genetic, postmortem and neuroimaging studies in schizophrenia patients showed alterations in different glutamatergic elements. Thus, glutamatergic system has emerged as a promising target for the treatment of schizophrenia, especially for symptoms not addressed by current anti

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Glutamate Function in Anxiety Disorders and OCD: Evidence from Clinical and Translational Studies,ering and disabilities on the people affected. Among the anxiety disorders described in DSM-5, the most prevalent and studied are generalized anxiety disorder (GAD), social anxiety disorder (SAD), and panic disorder (PD). Obsessive-compulsive disorder (OCD), although it shares many morphophysiopatho

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