Titlebook: Glucagon I; Pierre J. Lefèbvre (Professor of Medicine, Guest P Book 1983 Springer-Verlag Berlin Heidelberg 1983 Drogen.Glucagon.Hormone.Hy

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J?rg Niemann,Benedikt Reich,Carsten St?hr liver (SOKAL et al. 1964), isolated hepatocytes (G. and H. 1973; S. 1973; W. and I. 1973), and liver cells in primary culture (G. and C. 1968; W. and G. 1977). Numerous reports have stated similar observations, usually with liver preparations from rats or rabbits, but occasionally also from mice (A

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The Conformation of Glucagont study of the receptor-hormone complex is not possible at present. Instead we must examine the conformation of glucagon in aqueous solution, in crystals, in lipid micelles and other environments in order to establish the nature of the conformational dependence on intermolecular interactions. Here,

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Ontogeny and Phylogeny of the Glucagon Celle in 1975 when it was found that the hypothalamic peptide, somatostatin, oc-curred not only in neuronal cells, but also in endocrine cells in the antral mucosa and the pancreatic islets (P. et al. 1975). Thus, the D-cells (formerly o-cells) previously suspected of producing gastrin, were now shown t

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Radioreceptorassays for Glucagong the glucagon receptors as the binding reagent, might throw some light on the many specificity problems associated with the radioimmunologic determination of glucagon in biologic fluids (H. 1978 b). Not only are substances with glucagon-like immunoreactivity produced in many tissues outside the pan

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The Actions of Glucagon at Its Receptor: Regulation of Adenylate Cyclaseerally good, it must be emphasized that proof is lacking that regulation of cyclic AMP levels is the single action responsible for all effects of hormones or neurotransmitters. As a model process, however, hormonal regulation of cyclic AMP production has proven to be ideal since it can be observed w

Chromatic

Glucagon and Liver Glycogen Metabolism liver (SOKAL et al. 1964), isolated hepatocytes (G. and H. 1973; S. 1973; W. and I. 1973), and liver cells in primary culture (G. and C. 1968; W. and G. 1977). Numerous reports have stated similar observations, usually with liver preparations from rats or rabbits, but occasionally also from mice (A

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Book 1983nce its discovery in 1921 by BANTING and BEST, insulin has been irreplaceable for the treatment of the most severe forms of diabetes, whereas, in contrast, glucagon was until recently considered a relatively minor therapeutic agent. Third, whereas insulin is a compound which has been well characteri