Titlebook: Germ-Free Biology Experimental and Clinical Aspects; Proceedings of an In Edwin A. Mirand,Nathan Back Conference proceedings 1969 The Edito

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Erythropoietic Response of Germfree Mice to Erythropoietin, and there is a general diminution in the size of the lymph nodes, spleen, liver, and other organs comprising the reticuloendothelial system (1, 2). Since differences in hematological properties between the germfree and conventional animals have been observed, the question arose whether there were

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Viral Status of Germfree Rodents; Present and Future sex, age, diet, housing and microflora; for these factors are important for obtaining clear results and for correct interpretations of the results obtained. Considerable efforts have been directed toward producing and controlling animals as pure materials for experimentation. Germfree (GF) rodents

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Leukemia in Germfree AKR Mice Kaplan, 1967; Moloney, 1962; Furth et al., 1964; Gross, 1958 and 1961). Since this agent is vertically transmitted, it is expected that germfree mice would also develop leukemia, unless the presence of a microbial flora, or other horizontally transmitted viruses, contribute to its development. That

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Comparison Between the Effects of a Single Dose of a Chemical Carcinogen on Gnotobiotic and Conventi reject foreign skin grafts, than their conventional counterparts. They concluded that the degree of immunological impairment caused by neonatal thymectomy is intensified by factors associated with conventional environmental conditions.

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https://doi.org/10.1007/978-1-349-15350-3us, and lymphocytic choriomeningitis virus (7, 8); and it is likely that others will be added to this list. For these reasons we feel that the “germfree” mouse cannot serve as an experimental subject to delineate the exclusive role of viruses in carcinogenesis, since a virus-free mouse is not yet av

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