Titlebook: Genotoxicity and Carcinogenicity Testing of Pharmaceuticals; Michael J. Graziano,David Jacobson-Kram Book 2015 Springer International Publ

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Carcinogenicity Testing Strategies for Small Molecules,oaches are successfully deployed by industry scientists to support conclusions that positive rodent carcinogenicity study outcomes are related to compound class effects and are not human relevant, and examples are provided where product marketing has been enabled. Finally based on decades of such re

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Nonclinical Strategies for Investigating Potential Tumor Signals Detected in Clinical Trials,r, some nonclinical models to study tumor promotion and progression are discussed, and case studies are presented to illustrate various courses of follow-up investigations. Development and validation of innovative models for assessing tumor promotion and progression that are more human-based warrant

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https://doi.org/10.1007/978-3-319-22084-0Carcinogenicity; Genotoxicity; Immunomodulators; In Silico Predictive Tests; Regulatory; Tumor Signals

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