Titlebook: Genomics and Proteomics for Clinical Discovery and Development; Gy?rgy Marko-Varga Book 2014 Springer Science+Business Media Dordrecht 201

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Identification of Missing Proteins: Toward the Completion of Human Proteome, in size of collaborative efforts (International Human Genome Sequencing Consortium 2004). The social benefit of the knowledge generated is better understanding the expressions of genes in healthy and diseased conditions, which in turn can lead to better diagnosis and treatment of many diseases, inc

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hypotension

Standards for Proteomics Data Dissemination and Experiments Reporting,rieve all the information embedded in the result files, it is important to translate raw files into accepted standards (MIAPE (Minimum Information About a Proteomics Experiment) guidelines and HUPO-PSI xml formats). Data standardization enables to normalize the data obtained from distinct experiment

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Mass Spectrometry-Based Protein Sequencing Platforms,, which was improved by Pehr Edman (1949) in 1949. Until mid 1980s, the “Edman degradation” procedure had been used to determine the sequence of the N-terminal 30–40 amino acid residues in a protein routinely. The term “proteome”, linguistically equivalent to the concept of genome, was coined in 199

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Post-translational Modifications in the Human Proteome,20, 300 human genes. In addition, protein post-translational modifications will be characterized, with the initial goal of detecting phosphorylation, acetylation, and glycosylation sites in each protein. In this chapter, we provide an overview of known post-translational modifications, their known b

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Biomarker Discovery Utilizing Biobanking Archives and the Diagnostic Market,lized treatment has became the focus of the modern medicine. The various forms of diseases require new diagnostic, therapeutic and prognostic markers that can serve as targets for personalized drug development. Biobank establishment has a great importance globally, as biobank has been identified as

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Clinical Bioinformatics: A New Emerging Science of Biomarker Development,al than patients with more advanced cancer. More than 90 % 5-year survival rate was found to associated with the detection of cancers at the stage one (Etzioni et al. 2003), which need cancer-specific and sensitive biomarkers to diagnose and monitor timely therapeutic interventions (Ullah and Aatif