Titlebook: Genomic Applications in Pathology; George Jabboure Netto,Iris Schrijver Book 20151st edition Springer Science+Business Media New York 2015

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Kenya: Strategies for Development,ratories which are already using this technology currently apply existing clinical laboratory regulations to this novel category of high-complexity testing. Nevertheless, NGS technology holds great promise for the future despite some currently perceived barriers to implementation.

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Current Massively Parallel Sequencing Technologies: Platforms and Reporting Considerations all the coding regions of the genome (the exome), or of the whole genome itself in the clinical setting. This chapter reviews the major NGS platforms currently in use, as well as the interpretive and ethical challenges involved in filtering through the countless sequence variants observed to generate a meaningful clinical report.

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Emerging Next-Generation Sequencing Technologiesenges facing the development of new sequencing technologies. This chapter provides a broad overview of emerging new sequencing technologies including single-molecule and nanopore approaches. Potential applications in nucleic acid analysis which will be enabled by these technological advances are also highlighted.

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Circulating Tumor Cells: Enrichment and Genomic Applicationserstanding of cancer progression, the effects of therapy, and the identification of novel therapeutic targets. CTC evaluation is expected to become more widely used in both clinical and research settings.

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Implementation of Genome Sequencing Assaysratories which are already using this technology currently apply existing clinical laboratory regulations to this novel category of high-complexity testing. Nevertheless, NGS technology holds great promise for the future despite some currently perceived barriers to implementation.

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