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Titlebook: Genome Stability and Human Diseases; Heinz-Peter Nasheuer Book 2010 Springer Science+Business Media B.V. 2010 Chromosom.DNA.Viruses.genes.

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發(fā)表于 2025-3-21 18:36:02 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Genome Stability and Human Diseases
編輯Heinz-Peter Nasheuer
視頻videohttp://file.papertrans.cn/383/382854/382854.mp4
概述Discusses cancer cell biology in relation to Genome stability and Cell cycle regulation.Unique assembly of experts in these fields who wrote a comprehensive and deep up-to-date overview.Discusses mode
叢書名稱Subcellular Biochemistry
圖書封面Titlebook: Genome Stability and Human Diseases;  Heinz-Peter Nasheuer Book 2010 Springer Science+Business Media B.V. 2010 Chromosom.DNA.Viruses.genes.
描述.Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations...This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The c
出版日期Book 2010
關(guān)鍵詞Chromosom; DNA; Viruses; genes; genetic disorders; proteins; regulation; cytogenetics
版次1
doihttps://doi.org/10.1007/978-90-481-3471-7
isbn_softcover978-94-007-3125-7
isbn_ebook978-90-481-3471-7Series ISSN 0306-0225 Series E-ISSN 2542-8810
issn_series 0306-0225
copyrightSpringer Science+Business Media B.V. 2010
The information of publication is updating

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Deutsches Krebsforschungszentrum Heidelberguired for resumption of cell proliferation after DNA repair. Emerging evidence, although not without conflict, suggests that H3K56ac is not only present in human cells, but is similarly regulated and required for chromatin reassembly.
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DNA Polymerases and Mutagenesis in Human Cancers,rror prone repair of some kind of lesions by alternatives routes, thus leading to accumulation of mutations and contributing to genomic instability, a common feature of cancer cell. In this chapter, we present the role of each Pol in genome maintenance and highlight the connections between the malfunctioning of these enzymes and cancer progress.
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Fluorescence-Based Quantification of Pathway-Specific DNA Double-Strand Break Repair Activities: A nce the proteins of interest frequently have dual roles in DSB repair surveillance and checkpoint control, our assay procedure concomitantly corrects for transfection efficiencies, growth-, death-, and expression-related changes and also integrates the examination of the cell cycle status.
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