Titlebook: Genetics of Diabetes Mellitus; William L. Lowe Book 2001 Springer Science+Business Media New York 2001 Diabetes.Diabetes mellitus.genes.ge

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Type 1 Diabetes, Autoimmunity, and the MHC,haracterized by a more gradual onset of mild to severe hyperglycemia, typically in an obese adult (maturity onset diabetes). The vast majority (>90%) of patients with juvenile diabetes are dependent on exogenous insulin for survival (insulin-dependent diabetes, IDDM); while the vast majority (>80%)

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Genetics of Mitochondria-Related Forms of Syndromic Diabetes Mellitus,tion. Neurological defects such as psychomotor retardation, hypotonia or ataxia, myo-or cardiomyopathies, optic atrophy or sensorineural hearing loss are among the most frequent clinical symptoms observed in OXPHOS disorders. Because of their high metabolic activity, pancreatic I3-cells are also hig

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Candidate Genes for Type 2 Diabetes,ype 2 diabetes is polygenic, i.e., it is inherited in a non-Mendelian fashion and onset of the disease requires the simultaneous presence of a subset of susceptibility genes whose gene products affect insulin production, secretion or sensitivity (.–.). This has complicated efforts to identify diabet

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