| 書(shū)目名稱 | Genetic Recombination | | 副標(biāo)題 | Reviews and Protocol | | 編輯 | Alan S. Waldman | | 視頻video | http://file.papertrans.cn/383/382619/382619.mp4 | | 概述 | Includes supplementary material: | | 叢書(shū)名稱 | Methods in Molecular Biology | | 圖書(shū)封面 |  | | 描述 | Genetic recombination, in the broadest sense, can be defined as any process in which DNA sequences interact and undergo a transfer of information, producing new “recombinant” sequences that contain information from each of the original molecules. All organisms have the ability to carry out recombination, and this striking universality speaks to the essential role recombination plays in a variety of biological processes fundamentally important to the maintenance of life. Such processes include DNA repair, regulation of gene expression, disease etiology, meiotic chromosome segregation, and evolution. One important aspect of recombination is that it typically occurs only between sequences that display a high degree of sequence identity. The stringent requirement for homology helps to ensure that, under normal circumstances, a cell is protected from deleterious rearrangements since a swap of genetic information between two nearly identical sequences is not expected to dramatically alter a genome. Recombination between dissimilar sequences, which does happen on occasion, may have such harmful consequences as chromosomal translocations, deletions, or inversions. For many organisms, it is | | 出版日期 | Book 2004 | | 版次 | 1 | | doi | https://doi.org/10.1385/1592597610 | | isbn_softcover | 978-1-61737-442-5 | | isbn_ebook | 978-1-59259-761-1Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Humana Press 2004 |
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