Titlebook: Genes, Oncogenes, and Hormones; Advances in Cellular Robert B. Dickson,Marc E. Lippman Book 1992 Springer Science+Business Media New York 1

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Roles for transforming growth factors-β in the genesis, prevention, and treatment of breast cancerem determine the rate of tissue growth during embryogenesis, and later in response to damage or altered functional demand. The negative autocrine hypothesis proposed that any defect in a normal autocrine growth-inhibitory loop could lead to tumor formation in the affected cell type by upsetting this

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