Titlebook: Genes, Environments and Interactions; Evolutionary and Qua José M álvarez-Castro Book 2023 The Editor(s) (if applicable) and The Author(s),

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José M álvarez-CastroFirst treatise on genetic and environmental effects in the era of gene mapping and precision medicine.Provides a comprehensive theory of advanced models of genetic effects.Offers a revised way to lear

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Genetic Effects Over One Century,ral scientific practice. The achievement of the first satisfactory description of how Mendelian inheritance results in phenotypic resemblance between relatives, addressed in the previous chapter of this book, is an example of this. In this chapter, some of the most consequential advances made from t

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Variance Decomposition, Gene Mapping and Average Excesses: Orthogonality in the Spotlight,gical meaning. In the previous chapters, we have achieved an advanced model of genetic effects both at the individual and at the population levels, applicable to very complex genetic architectures and to non-equilibrium populations. Such theory is at the core of quantitative genetics and of a major

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Applied Cases of Advanced Genetic Modelling,addresses the one-locus three-allele polymorphism of the . human enzyme in Europe. The genetic variance decomposition is obtained with NOIA and it is used to estimate fitness values explaining the observed genotype frequencies as those of a stable equilibrium. The second case addresses the historica

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