Titlebook: General Methods in Biomarker Research and their Applications; Victor R. Preedy,Vinood B. Patel Reference work 2015 Springer Science+Busine

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https://doi.org/10.1007/978-3-319-42792-8uctive stress, leading to cellular damage and dysregulation. Excessive reactive oxygen species (ROS) deteriorates vascular functions and promotes vascular diseases through multiple pathways. Recently, cyclophilin A (CyPA) has been shown to be secreted from vascular smooth muscle cells (VSMC) and to

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https://doi.org/10.1007/978-94-007-7696-8Application to prognosis; Biomarkers in disease; Cancer Research; Discovery of biomarkers; High throughp

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Springer Science+Business Media Dordrecht 2015

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High-Throughput Approaches to Biomarker Discovery and Challenges of Subsequent Validationredictions of the imminent breakthroughs in our understanding of human diseases and making predictive diagnostics easy, however, turned out to be largely over optimistic..We argue that this situation is not coincidental, but rather is caused by the statistical properties of the data collected. A typ

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Toxicogenomic and Pharmacogenomic Biomarkers for Drug Discovery and Personalized Medicines of drug development may necessitate a return to seed compound screening, because toxicity is often inherent to the basic structure and is thus difficult to be eliminated by minor modification. An urgent need therefore exists for safety biomarkers that enable prediction of potential toxicity and pr

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Glycome as Biomarkerslycans of glycoconjugates, glycomic approaches to discover novel biomarkers are just on the rise. Routinely used glycan biomarkers have been developed using traditional immunological techniques and monoclonal antibody technology. Recent progress in the development of analytical methodologies and str

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Flow Cytometry as Platform for Biomarker Discovery and Clinical Validationplantation, autoimmunity, tumor immunology, chemotherapy, etc.), making it highly useful not only in the discovery of new biomarkers but also in clinical validation and routine implementation. FC simultaneously provides information about the phenotypic and functional characteristics of cells and ena

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