Titlebook: Gene Vaccines; Josef Thalhamer,Richard Weiss,Sandra Scheiblhofer Book 2012 Springer-Verlag/Wien 2012 RNA and DNA vaccines.antigen-specific

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Messenger RNA Vaccines,r RNA (mRNA) vaccines have found entry into clinical development. Through improved vector design, formulation, and delivery, mRNA, initially perceived as unstable and difficult to manipulate, has been developed into a convenient, efficacious, and flexible vaccine platform. Importantly, the same prod

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Book 2012 After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hur

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cal use objective comparison of different methods and protocThe induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies di

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John C. Parker,Lee R. Berkowitz as unstable and difficult to manipulate, has been developed into a convenient, efficacious, and flexible vaccine platform. Importantly, the same production process can be used to produce a variety of different vaccines, independent of the specifics of particular constructs, which ultimately decreases costs and development time.

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https://doi.org/10.1007/978-1-84882-521-5re conventional vaccines, killed or modified live vaccines. Until now, the only animal infection eradicated by vaccination is rinderpest, and for numerous pathogens no effective and safe vaccine is available. There is an undisputed urgent need to develop novel vaccination strategies with improved efficacy.