Titlebook: Gene Therapy in Inflammatory Diseases; Christopher H. Evans,Paul D. Robbins Book 2000 Springer Basel AG 2000 Arthritis.DNA.apoptosis.carti

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Animal models of arthritis generated by gene transfer,ystemic disorder, the most commonly affected sites are the wrist, knees and metacarpophalangeal joints. The debilitating effects of the disease occur progressively over time. The synovium, normally a thin layer of tissue that lines the internal surfaces of the joint capsule, becomes dramatically thi

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,Gene therapy for inflammatory diseases — basic concepts,Although inflammatory diseases vary widely in the organs they affect and the symptoms they produce, as well as in their chronicity, morbidity and mortality, they share common pathophysiological pathways [1]. These pathways are illustrated in Figure 1.

Initial

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Klaus D. Niemann,Stephen Fedtketreatments to acquired diseases, such as cancer, autoimmune, and chronic inflammatory conditions. The concept of gene therapy for rheumatoid arthritis (RA) was proposed as an alternative to inefficient conventional drug delivery to the affected joints [1]. In this approach, introduction of exogeneou