Titlebook: Gene Therapy for Neurological Disorders and Brain Tumors; E. Antonio Chiocca,Xandra O. Breakefield Book 1998 Springer Science+Business Med

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Gene Therapy for Neurological Disorders and Brain Tumors

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Gene Therapy for Neurological Disorders and Brain Tumors978-1-59259-478-8

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Retrovirus Vectors and Regulatable Promotersin host-cells in the process of replicating and synthesizing their own genomic DNA (an exception is in the human immunodeficiency virus [HIV] family of retroviruses), which allows the targeting of the virus to rapidly dividing cells and not postmitotic cells .. The viral genes in the vector genome w

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HSV Recombinant Vectorsrly (IE), early, and late. The latent infection occurs in sensory ganglia and is characterized by a complete absence of lytic gene expression but for the synthesis of a set of transcripts (of unclear function) referred to as the latency-associated transcripts (LATs). The potential applications for a

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AAV Vectors, integration occurs in a site-specific fashion: The majority of AAV sequences are found in a restricted area (AAVS1) on chromosome 19g13.3-qter .. This integration has not been associated with any ill effects on the host cell. The lack of pathogenicity and the ability to integrate site-specifically

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Promoters for Expression of Gene Products within Neurons and Gliarapy. It includes an overview of the general properties of transcriptional regulation, an analysis of the mechanisms by which cell-specific gene expression is achieved by interactions between promoters, transcription factors, chromatin, and methylation, and summarizes transgenic studies of brain-spe

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Immune Response to Viral Vectors two clinical trials are currently underway using adenovirus vectors to treat gliomas .. Vector applications can be categorized on the basis of the desired duration of transgene expression and the effect of the immune response on the target cell. For example, correction of such disorders as Parkinso

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Tumor Suppressor Gene Therapy for Brain Tumorsto take advantage of the underlying genetic abnormalities of tumor cells, those that contribute to the unregulated growth of cancer cells, prevent apoptosis, activate angiogenic factors, induce proliferation, and promote invasiveness. One of the most promising new therapeutic approaches involves the