Titlebook: Gene Therapy for HIV; From Inception to a Gerhard Bauer,Joseph S. Anderson Book 2014 Gerhard Bauer and Joseph S. Anderson 2014 Anti-HIV ge

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Principles of Gene Therapy,shed by the insertion of naked DNA and the application of nonviral gene transfer (transfection) or viral gene transfer (transduction) methods. These methods vary widely in their gene transfer efficacy and also in the duration of expression of the transferred gene. For durable gene expression, retrov

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History of Gene Therapy,he first retroviral-mediated gene therapy clinical trials started in 1990, and the first stem cell gene therapy clinical trial (ADA deficiency), also retrovirally mediated, was initiated in 1994. The first stem cell gene therapy clinical trial for pediatric HIV was conducted in 1997, followed by a s

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Stem Cells for HIV Gene Therapy, types of stem cells. They can be obtained either from the bone marrow or by mobilization and subsequent apheresis from the peripheral blood. After transplantation, there is no rejection issue; however, a high-enough transduction efficiency to elicit a clinical benefit is difficult to obtain. Select

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Clinical Applications of HIV Gene Therapy,by several groups: T cell gene therapy and stem cell gene therapy clinical trials. Both have their unique advantages and disadvantages, with T cell gene therapy offering easier access to HIV target cells and greater transduction efficiencies, however, with the necessity to repeat the procedure to pr

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Is a Cure for HIV Possible?,nough number of HIV-resistant hematopoietic stem cells is transplanted into an HIV-infected recipient, eventually creating an immune system that can control the virus. This has been demonstrated in one patient who received a bone marrow transplant from a donor with a naturally occurring CCR5 deletio