Titlebook: Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine; Johnny Huard,Freddie H. Fu Book 2000 Birkh?user Boston 2000 Osteog

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https://doi.org/10.1057/9781137314130pbell 1969; Mankin 1982). Although many repair techniques have been proposed over the past 4 decades, none has successfully regenerated long-lasting hyaline cartilage tissue to replace damaged cartilage. In fact, most of the surgical interventions to repair damaged cartilage have been directed towar

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,Economic Developments 1930–56,nd important phase of medical progress was the discovery of vaccination, which not only led to an understanding of the complexity of the immune response, but also to a systematic method of treating a variety of transmissible diseases. The third important step in the development of medicine was the t

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John Clare and the Triumph of Little Things,n orthopaedic treatment. However, numerous gene transfer approaches, including direct (in vivo), indirect (ex vivo), and systemic delivery of nonviral and viral vectors, have been hampered by limitations such as low transfection efficiency, immunologic responses, cytotoxic effects, and maturation-de

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Class Conflicts Between Fishermen,ations. However, despite tremendous progress, many questions remain unanswered. This chapter reviews the current status of muscle-based tissue engineering for musculoskeletal disorders and discusses the focus of ongoing research.

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Cardiac

On the Influences of Economic Change,ion for stem cells involves the treatment of tissue losses, which requires that large numbers of cells be available for transplantation. Similar issues arise with respect to providing sufficient numbers of cells for gene therapy.

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Nuance

Vectors for Gene Transfer to Jointsnes as therapeutic agents can results in persistent expression locally at the site of disease, bypassing the need for multiple injections and preventing possible side effects associated with systemic administration.