Titlebook: Gene Therapy; Principles and Appli Thomas Blankenstein Book 1999 Birkh?user Verlag 1999 DNA.HIV.bacteria.biotechnology.cancer.gene expressi

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Lorena Melga?o,Katharine S. Willisrking studies were the first gene transfer protocols to enter clinical practice. The principal objective of a gene marking study is to introduce, in the target cells, a gene which does not modify the function of the cells but allows them to be detected, providing information on survival, distributio

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I lobi frontali e le loro aree principali,icularly true for hematopoietic disorders because the efficiency of gene transfer is limited and stable expression of transgenes in bone marrow has been found difficult to accomplish (Miller, 1990). In preclinical primate studies as well as in clinical trials, the percentage of hematopoietic cells e

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https://doi.org/10.1007/978-981-99-8699-6ransforming retro-viruses are known to carry specific genes likely to be responsible for induction of the malignant phenotype in the cells they infect [2–5]. These genes, termed viral-oncogenes (v-onc), are derived from highly conserved, normal cellular genes which were almost certainly incorporated

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Introduction likely to have farreaching consequences in the practice of medicine, as we enter the next millennium. Currently, there are over 200 seperate active clinical trials with over 2,500 patients entered. These studies involve over 20 countries and include patients with a wide range of diseases, including

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Retroviral Vectorsdiseases, from cancer to virus infection to arthritis. Although the current vectors have worked efficiently for gene transfer in the initial trials, it is likely that modifications of both the vector and packaging lines should result in even higher titer, targetable viruses with elevated and/or regu

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