Titlebook: Gene Therapeutics; Methods and Applicat Jon A. Wolff Book 1994 Birkh?user Boston 1994 DNA.Promoter.Translation.gene expression.gene therapy

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Xiaoying Dong,Yan Yu,Jiali Zhouome equally apparent that backbone or pendant oligonucleotide modifications can alter olionucleotide uptake characteristics, although not always in the way intended. In this chapter, we will review the current state of knowledge concerning internalization pathways for modified and unmodified oligonu

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Possible Mechanisms of DNA Uptake in Skeletal Musclebiological membranes are, at this time, mostly speculative and require more research to fully define the processes involved in polynucleotide transport. This chapter will discuss what is known about the uptake of naked foreign DNA by muscle cells after intramuscular injection or implantation as well

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Receptor-Mediated Gene Delivery Employing Adenovirus-Polylysine-DNA Complexesween the negatively charged DNA and the positively charged DNA-binding domain serves not only to bind the DNA, but also to condense it into a compact toroid structure (Wagner et al., 1991a). As the ligand is covalently linked to the polylysine DNA-binding domain, after binding of the DNA, at least a

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In Vivo Gene Therapy via Receptor-Mediated DNA Deliveryerapy strategy would be available, the current inability to achieve permanent transgene expression necessitates periodic retreatments, making these procedures highly cost-ineffective over the long term.

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Cellular Internalization of Oligodeoxynucleotidesome equally apparent that backbone or pendant oligonucleotide modifications can alter olionucleotide uptake characteristics, although not always in the way intended. In this chapter, we will review the current state of knowledge concerning internalization pathways for modified and unmodified oligonu