Titlebook: Gene Function Analysis; Michael F. Ochs Book 2014Latest edition Springer Science+Business Media, LLC 2014 functional genomic analysis.gene

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Pattern Identification in Time-Course Gene Expression Data with the CoGAPS Matrix Factorizationonality constraint in standard pattern-finding algorithms, including notably principal components analysis (PCA), confounds expression changes resulting from simultaneous, non-orthogonal biological processes. Previously, we have shown that Markov chain Monte Carlo nonnegative matrix factorization al

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Determining the Effect of DNA Methylation on Gene Expression in Cancer Cells known to be associated with gene transcription by interfering with DNA-binding proteins, such as transcription factors. DNA methylation is closely related to tumorigenesis, and the methylation state of some genes can be used as a biomarker for tumorigenesis. Aberrant DNA methylation of genomic regi

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Reverse Engineering Transcriptional Gene Networks in Subheading 1, where the different types of networks are discussed. The chapter then guides the readers through a data-gathering process in order to build a compendium of gene expression profiles from a public repository. Gene expression profiles are then discretized and a statistical relationshi

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Integrating , Resources to Map a Signaling Networkta and greatly enhance hypothesis generation. Protein interaction and functional networks are not simply new renditions of existing data: they provide the opportunity to gain insights into the specific physical and functional role a protein plays as part of the biological system. In this chapter, we

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A Method for Inducible Gene Over-Expression and Down-Regulation in Emerging Model Species Using ,the exploration of gene function, either via knock-downs of endogenous genes or via over-expression and ectopic expression of transgenes. We constructed a new vector called . that can be used to over-express or down-regulate genes in organisms amenable to germ-line transformation by the . transposab

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Construction and Application of Site-Specific Artificial Nucleases for Targeted Gene Editing authors provide detailed protocols for rapidly constructing zinc finger nucleases (ZFNs) and TALE nucleases (TALENs) and evaluating their activity for the targeted generation of InDels within the zebrafish genome.

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