Titlebook: Gene Expression in Normal and Transformed Cells; J. E. Celis,R. Bravo Book 1983 Springer Science+Business Media New York 1983 DNA.gene exp

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rimentation has been concerned with the total cellular response to transformation (1–5), while the other has been directed to search for changes in few cellular proteins whose expression is presumed to represent primary lesions in cells transformed with DNA or RNA tumour viruses (6–9). Both experime

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known. Some of the features of Down syndrome are mental retardation, a high incidence of cardiac defects and predisposition for development of acute myeloblasts and acute lymphocytic leukemia (1). Individuals with this disorder display features of premature ageing (2, 3); those who survive into thei

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eneity (1, 2). Assuming that at least some of these proteins participate in the process of differentiation and regulation of genetic transcription, they should be cell specific. Because of their unique selectivity and sensitivity, immunological procedures are well suited for probing the cell and tis

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