Titlebook: Gene Expression; General and Cell-Typ Michael Karin Book 1993 Birkh?user Boston 1993 gene expression.genes.molecular biology.transcription

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Control of Transcription and Cellular Proliferation by cAMP,g nuclear factor. Because all the known cellular effects of cAMP occur via cAMP-dependent protein kinase, it appears that phosphorylation is the most likely mechanism by which cAMP would regulate gene expression.

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Agnosia

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Transcription Factors Controlling Muscle-Specific Gene Expression, biology. Skeletal muscle has provided an important system for investigating this problem because differentiation of skeletal myoblasts is accompanied by the coordinate induction of a battery of genetically unlinked muscle-specific genes whose products are required for the specialized functions of t

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Transcriptional Control of Pituitary Gene Expression,Jurgens, 1991; Gehring, 1987; Ingham, 1988; Ingham and Martinez Arias, 1992; Moses, 1991; Nusslein-Volhard and Wieschaus 1980; Nusslein-Volhard et al., 1987; Perkins and Perrimon, 1991; St. Johnston and Nusslein-Volhard, 1992) and the nematode . (Davidson, 1990; Sternberg and Horvitz, 1991). The dev

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Plasticity of the Differentiated State,, 1992; Wolpert, 1969, 1989). But the question of how, once established, the differentiated state is maintained has received less attention. By what molecular mechanism is the differentiated state of a cell regulated? That question is the focus of this chapter.

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Gene Expression in Hematopoietic Cells: The ,-Globin Gene,tire .-globin gene locus is maintained in an “active” nucleosomal conformation throughout erythroid development although the locus is packaged in an “inactive” conformation in nonexpressing cells. Once the chromosomal locus is activated, individual globin genes are differentially regulated by .-acti