Titlebook: Gene Delivery to Mammalian Cells; Volume 2: Viral Gene William C. Heiser Book 2004 Humana Press 2004

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https://doi.org/10.1007/978-3-642-23614-3uman diseases. AAV’s inability to self-propagate, ability to be maintained as an episome in the transduced cell, and relatively innocuous effects on the immune system make it the vector of choice for prolonged in vivo gene expression. AAV type 2 is the most commonly used serotype for gene delivery.

PHONE

Research Design and Methodology,AAV vectors are devoid of viral-coding sequences and may efficiently transfer genes to nondividing cells such as muscle fibers or hepatocytes following in vivo transduction (.–.). Recombinant AAV can be administered to skeletal muscle of experimental animals and, as recently documented in a Phase I

沙漠

https://doi.org/10.1007/978-3-030-20663-5ere prolonged expression of genes in the liver is required, adeno-associated virus (AAV) has proven to be an effective tool for in vivo gene transfer. High-level, persistent hepatic expression has been achieved in a number of experimental systems following a single treatment with AAV in murine and l

共棲

Alpaslan ?zerdem,Sukanya Podder(.–.) makes them excellent tools for gene transfer. One tissue of interest for gene transfer is the lung epithelium, which is afflicted in cystic fibrosis (CF). However, although initial animal studies done with vectors based on A AV type 2 have demonstrated transduction in multiple cells types in t

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Brett Pierce,Christabel Kalaiselvischemic heart disease, and cardiomyopathy. In addition to its potential for treatment of disease, myocardial gene transfer is useful for the analysis of gene expression and promoter function and for generating animal models of human disease such as pulmonary hypertension. The ideal vector for myocar

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catagen

John Cockburn,Jane Kabubo-Mariarad with those that have been published on targeting normal cells. A major reason for this can be attributed to the biology of the vector itself. AAV, being a nonpathogenic vector capable of providing transgene integration and long-term expression, is ideally suited for the correction of metabolic def

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Gene Delivery to Mammalian Cells978-1-59259-650-8Series ISSN 1064-3745 Series E-ISSN 1940-6029

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矛盾心理

Gene Delivery to the Mouse Brain with Adeno-Associated Virusutic genes to the mammalian brain. An attractive feature of AAV is that all the viral-coding sequences are removed when engineering the recombinant genome, thereby limiting the extent of cell toxicity and immune response that are often associated with viral gene transcription (.).