Titlebook: Gangliosides and Modulation of Neuronal Functions; Hinrich Rahmann Conference proceedings 1987 Springer-Verlag Berlin Heidelberg 1987 Calc

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Fundamentals of the Application of MS and NMR in the Study of Ganglioside Structurewith gangliosides ever since their discovery 50 years ago. Whereas most of early work on ganglioside structure was based on more or less degradative chemical methods (1–5), physicochemical methods like mass spectrometry and high resolution nuclear magnetic resonance spectroscopy as a non-destructive

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Fundamentals of Physico-Chemical Properties of Gangliosides in Solutionsidue, give the hydrophobic properties to the ganglioside molecule, while the polar carbohydrate portion is responsible for the high hydrophilicity of the molecule. This leeds them to form aggregates in solution, the properties of which depend strongly on even small changes in the hydrophilic or the

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Peculiarities of Ganglioside-CA2+-Interactionsof the other physiologically relevant cations, for instance magnesium, calcium is generally well known for its more variable complex binding-possibilities, especially with regard to the coordination numbers as well as to the length and the angle of binding or the degree of hydration (1, 2).

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