Titlebook: Gadd45 Stress Sensor Genes; M. Raza Zaidi,Dan A. Liebermann Book 2022Latest edition The Editor(s) (if applicable) and The Author(s), under

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https://doi.org/10.1007/978-3-030-94804-7gene function; proteins; stress sensors; stress signaling; cancer; innate immunity

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Advances in Applied Strategic Mine Planningng DNA repair, cell cycle arrest, and apoptosis. Here, we review current literature investigating GADD45 family members as they relate to normal development and carcinogenesis. We first describe how modulation of GADD45 in model organisms has facilitated our understanding of roles for GADD45 family

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Architectural Acoustics for Practitioners,normal blood cell development and leukemia. Each of the Gadd45 genes was shown to be regulated independently in myeloid cells in response to cytokine stimulation modulating blood cell survival and differentiation, including maintaining the quiescent stem cell pool. Gadd45a and Gadd45b were also show

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Advances in Architectural Geometry 2012enotoxic/physiological stress. They are involved in regulation of various cellular functions such as DNA repair, senescence, and cell cycle control. Gadd45 family of genes serve as tumor suppressors in response to different stimuli and defects in Gadd45 pathway can give rise to oncogenesis. More rec

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Advances in Architectural Geometry 2014es has to distinguish between self and non-self, but also between harmless and dangerous. To do so, the immune system developed an innate and an adaptive branch that provide immediate and long-lasting protection, respectively. Furthermore, the immune system is composed of different cell types, which

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https://doi.org/10.1007/978-3-642-60612-0 has accumulated that Gadd45a deficiency results in escape of mouse embryo fibroblasts from senescence, whereas Gadd45b deficiency promotes premature senescence and skin aging. Moreover, recently Gadd45b deficiency was found to promote senescence and attenuate liver fibrosis, whereas Gadd45a was obs