Titlebook: GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity; Denis J. Dupré,Terence E. Hébert,Ralf Jockers Book 2012 Spri

好色

,Preferential Assembly of G-αβγ Complexes Directed by the γ Subunits,s of the G-αβγ combinations that actually exist in physiological setting are largely unknown. Moreover, there is uncertainty regarding whether the individual subunits associate by a random process, or combine by a regulated process to form quasi-stable G-αβγ complexes. In this chapter, we will focus

Preamble

G Protein Trafficking,tivated by an appropriate G protein-coupled receptor. Once activated, the GTP-bound Gα and the free Gβγ are able to regulate plasma membrane-localized effectors, such as adenylyl cyclase, phospholipase C-β, RhoGEFs and ion channels. Hydrolysis of GTP by the Gα subunit returns the G protein to the in

Guileless

investigate

Presbyopia

BIPED

0306-0225 tions of manuscripts made from experts in the fieldMain Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to und

外形

Keshan-disease

Introduction to the Original Guide,of the receptors remain poorly defined. In this chapter, I will discuss current advances in understanding post-Golgi transport of GPCRs by focusing on specific motifs or sequences that may function as sorting signals regulating export from the Golgi and subsequent transport to the plasma membrane of GPCRs.

嘴唇可修剪

A Guide to Addiction and Its Treatmentintracellular compartments. The regulated export of GPCRs is also controlled by external stimuli and might represent an adaptive mechanism to specific physiological constraints, such as the sustained activation of the CCR5 chemokine receptor in the context of chemotaxis.

MIRE

GPCR Oligomerization: Contribution to Receptor Biogenesis,he ER to the trans-golgi network. The assembly of several GPCRs into a quaternary structure is started in the ER, before cell surface delivery, and helps in the correct expression of the GPCRs. This review will mainly focus on the role of GPCR oligomerization in receptor biogenesis.